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How to improve the quality of function ‘image.save()’？

I saved the image to the clipboard, and when I read the image information from the clipboard and saved it locally, the image quality changed. How can I save it to maintain the original high quality?
from PIL import ImageGrab
im = ImageGrab.grabclipboard()
im.save('somefile.png','PNG')
I tried adding the parameter 'quality=95' in im.save(), but it didn't work. The original image quality is 131K, and the saved image is 112K.

The size of the file is not directly related to the quality of the image. It also depends on how efficiently the encoder does its job. As it is PNG, the process is lossless, so you don't need to worry - the quality is retained.
Note that the quality parameter has a different meaning when saving JPEG files versus PNG files:
With JPEG files, if you specify a lower quality you are effectively allowing the encoder to discard more information and give up image quality in return for a smaller file size.
With PNG, your encoding and decoding are lossless. The quality is a hint to the decoder as to how much time to spend compressing the file (always losslessly) and about the types of filtering/encoding that may suit best. It is more akin to the parameter to gzip like --best or --fast.
Further information about PNG format is here on Wikipedia.
Without analysing the content of the two images it is impossible to say why the sizes differ - there could be many reasons:
One encoder may have noticed that the image contains fewer than 256 colours and so has decided to use a palette whereas the other may not have done. That could make the images size differ by a factor of 3 times, yet the quality would be identical.
One encoder may use a larger buffer and spend longer looking for repeating patterns in the image. For a simplistic example, imagine the image was 32,000 pixels wide and each line was the same as the one above. If one encoder uses an 8kB buffer, it can never spot that the image just repeats over and over down the page so it has to encode every single line in full, whereas an encoder with a 64kB buffer might just be able to use 1 byte per line and use the PNG filtering to say "same as line above".
One encoder might decide, on grounds of simplicity of code or for lack of code space, to always encode the data in a 16-bit version even if it could use just 8 bits.
One encoder might decide it is always going to store an alpha layer even if it is opaque because that may make the code/data cleaner simpler.
One encoder may always elect to do no filtering, whilst the other has the code required to do sub, up, average or Paeth filtering.
One encoder may not have enough memory to hold the entire image, so it may have to use a simplistic approach to be assured that it can handle whatever turns up later in the image stream.
I just made these examples up - don't take them was gospel - I am just trying to illustrate some possibilities.

To reproduce an exact copy of file from a clipboard, the only way is if the clipboard contains a byte-for-byte copy of the original. This does not happen when the content comes from the "Copy" function in a program.
In theory a program could be created to do that by setting a blob-type object with a copy of the original file, but that would be highly inefficient and defeat the purpose of the clipboard.
Some points:
- When you copy into the clipboard using the file manager, the clipboard will have a reference to the original file (not the entire file which can potentially be much larger than ram)
- Most programs will set the clipboard contents to some "useful version" of the displayed or selected data. This is very much subject to interpretation by the creator of the program.
- Parsing the clipboard content when reading an image is again subject to the whims of the library used to process the data and pack it back into an image format.
Generally if you want to copy a file exactly you will be better off just copying the original file.
Having said that: Evaluate the purpose of the copy-paste process and decide whether the data you get from the clipboard is "good enough" for the intended purpose. This obviously depends on what you want to use it for.

ImageMagick: scale PNG image with a maximum file-size

How would you scale/optimize/minimally output a PNG image so that it just falls below a certain maximum file size? (The input sources are various - PDF, JPEG, GIF, TIFF...)
I've looked in many places but can't find an answer to this question.
In ImageMagick a JPEG output can do this with extent (see e.g. ImageMagick: scale JPEG image with a maximum file-size), but there doesn't seem to be an equivalent for other file formats e.g. PNG.
I could use Wand or PIL in a loop (preference for python) until the filesize is below a certain value, but for 1000s of images this will have a large I/O overhead unless there's a way to predict/estimate the filesize without writing it out first. Perhaps this is the only option.
I could also wrap the various (macOS) command-line tools in python.
Additionally, I only want to do any compression at all where it's absolutely necessary (the source is mainly text), which leaves a choice of compression algorithms.
Thanks for all help.
PS Other relevant questions:
Scale image according a maximum file size
Compress a PNG image with ImageMagick
python set maximum file size when converting (pdf) to jpeg using e.g. Wand
Edit: https://stackoverflow.com/a/40588202/1021819 is quite close too - though the exact code there already (inevitably?) makes some choices about how to go about reducing the file size (resize in that case). Perhaps there is no generalized way to do this without a multi-dimensional search.
Also, since the input files are PDFs, can this even be done with PIL? The first choice is about rasterization, for which I have been using Wand.
https://stackoverflow.com/a/34618887/1021819 is also useful, in that it uses Wand, so putting that operation within the binary-chop loop seems to be a way forward.

With PNG there is no tradeoff of compression method and visual appearance because PNG is lossless. Just go for the smallest possible file, using
my "pngcrush" application, "optipng", "zopflipng" or the like.
If you need a smaller file than any of those can produce, try reducing the number of colors to 255 or fewer, which will allow the PNG codec to produce an indexed-color PNG (color-type 3) which is around 1/3 of the filesize of an RGB PNG. You can use ImageMagick's "-colors 255" option to do this. However, I recommend the "pngquant" application for this; it does a better job than IM does in most cases.

Using gdcm (Grassroots DICOM) to Decompress DICOM Image Data

Is it possible to use the Python wrappers for GDCM to decode the image data in a DICOM file?
I have a byte array / string with the bytes of the image data in a DICOM file (i.e. the contents of tag 7fe0,0010 ("Pixel Data")) and I want to decode the image to something raw RGB or greyscale.
I am thinking of something along the lines of this but working with just the image data and not a path to the actual DICOM file itself.

You can read the examples, there is one that shows how one can take an input compressed DICOM and convert it to an uncompressed one. See the code online here:
Decompress Image
If you are a big fan of NumPy, checkout:
This module add support for converting a gdcm.Image to a numpy array.
This is sort of a low level example, which shows how to retrieve that actual raw buffer of the image.
A much nicer class for handling Transfer Syntax conversion would be to use gdcm.ImageChangeTransferSyntax class (allow decompression of icon)
gdcm::ImageChangeTransferSyntax Class Reference
If you do not mind reading a little C++, you can trivially convert the following code from C++ to Python:
Compress Image
Pay attention that this example is actually compressing the image rather than decompressing it.
Finally if you really only have access to the data values contains in the Pixel Data attribute, then you should really have a look at (C# syntax should be close to Python syntax):
Decompress JPEG File
This example shows how one can decompress a JPEG Lossless, Nonhierarchical, First- Order Prediction file. The JPEG data is read from file but it should work if the data is already in memory for your case.

Checking if an image format is Lossless in Python?

I am working on an application that requires images submitted to it to be lossless. Currently I am opening the image with PIL and checking if the "format" attribute is a lossless format. This requires me to manually keep a list of formats, and I have no idea if, for instance, a jpeg that was submitted just happens to have the lossless variant applied.
import PIL
import PIL.Image
def validate_image(path):
img = PIL.Image.open(path)
if not img.format.lower() in ['bmp', 'gif', 'png', ...]:
raise Exception("File %s has invalid image format %s" % (path, img.format))
Is there a better way to check if the image file is lossless?

I think I now understand things: You want to open the images via PIL. You want to reject lossy images because you're doing scientific processing of some kind that needs all that lost data because information that's unimportant for human visual processing is important for your algorithms.
PIL does not have any kind of interface at the top level to distinguish different types of compression. You could reach inside the image decoders and assume that anything that uses the "raw" decoder is lossless, but even if you wanted to do that, that's too limited—it'll rule out GIF, LZW-compressed TIFF, etc. along with JPEG, JPEG-compressed TIFF, etc.
Keep in mind that the real problem is here is messaging and documentation—managing user expectations. The check for lossy images is really just a heuristic, a way to catch the more obvious mistakes and remind the user what the requirements are. So, you don't need something perfect, but having something pretty good may be helpful anyway.
So, there are only a few options, none of them very good:
Hack up PIL's decoder source to retain the encoding information and pass it up to the top level. This is, obviously, going to take some non-trivial work, in 30 different importers, possibly involving C as well as Python, and it will result in a patch that you have to maintain against a (slowly-)evolving codebase—although of course you can always submit it upstream and hope that it makes it into future versions of PIL.
Dig into the decoders themselves to get the information at runtime. The only semi-standard thing you can really find is whether they use the raw decoder or the bit decoder, which isn't useful at all (many lossless formats will need the bit decoder), so you'll probably end up reading all 30 importers and writing a dozen or so pieces of code to extract information from them.
Use another library along with (or in place of) PIL. For example, while ImageMagick is definitely not significantly easier than PIL, it does have an API to tell you what type of compression an image file uses. Basically, if it's UndefinedCompression or JPEGCompression it's lossy, anything else, it's lossless. The major downside (besides needing to install two image libraries) is that there will be files that PIL can open but IM can't, and vice-versa, and multi-image files that PIL and IM handle differently, and so on.
Do what you're already doing. Read through the 30 importers to make a list of which are lossy and which are lossless. To handle cases like JPEG and TIFF that are sometimes lossless, you may want to write code that doesn't flat-out reject them, but instead gives a warning saying "These files may be lossy. Are you sure you want to import them?" (Or, alternatively, just offer an "I know what I'm doing" override for all lossy formats, and then just consider JPEG and TIFF lossy.)
For many use cases, I'd be very wary of going with #4, but for yours, it actually seems pretty reasonable. You're not trying to block lossy images because your code will crash, or for security reasons, or anything like that; you're just trying to warn people that they're going to waste a lot of time getting useless information if they submit a JPEG, right?

Getting pixel data from a PythonMagick image?

Does anyone know a way get the pixel data from a PythonMagick.Image instance without having to write it to disk first?
For instance, I can read in an image using:
import PythonMagick
im = PythonMagick.Image('image.jp2')
I would now like to be able to get the uncompressed image data so that I can use it in something else like NumPy or matplotlib, but I can't seem to find any way to do this. I would just use matplotlib or PIL directly but the image format I'm reading in is JPEG 2000 which is only supported by PythonMagick as far as I know.
Any suggestions?

Disclaimer: I don't have PythonMagick built where I am right now and am no expert, so (1) any or all of the following may be wrong, (2) it will certainly be less specific than you'd like, and (3) if someone else knows better I hope they won't be put off by seeing an answer already here. Anyway:
From a quick look at the code, it looks as if you can read pixel values one by one using the pixelColor method on the Image class. This returns a PythonMagick.Color value, from which you can extract R,G,B components. The underlying C++ library supports reading out lots of pixels at a time using Image::writePixels, which is also present in PythonMagick.Image; but I think the proper use of that method depends on other things that aren't implemented in PythonMagick. That's a pity, because I bet it would have been much much more efficient than reading one pixel at a time.
Alternatively and probably better, it looks as if you can write the contents of the image to a PythonMagick.Blob object in memory, which basically does the same as writing to a file only without the file :-). You can choose what format it should write in, just as you do when writing to a file. There seems to be something called get_blob_data for extracting the contents of a Blob. Something like this:
im = PythonMagick.Image('image.jp2')
blob = PythonMagick.Blob()
im.write(blob, "png")
data = PythonMagick.get_blob_data(blob)
The resulting data is, I think, a Python string whose bytes are the binary representation of the image. (I'm assuming you're using Python 2.x, where the string type is 8-bit. I don't know whether PythonMagick works with 3.x.) I think there are some formats that are basically raw pixel data; try "RGB". You can then extract the contents via lots of struct.unpack or whatever.