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How to convert mathematical numbers into floats

In python, is there a way or even build in Function to convert a string into a float? Specifically:+1.488763E+01 into 14.88763 ?

What you have is a valid float literal. Convert it to a float, then convert the result back to a str
>>> '{:f}'.format(float('+1.488763E+01'))
'14.887630'
The format method is used to force the value to be represented as a fixed-point value, rather than in exponential notation. For example,
>>> str(float('1e20'))
'1e+20'
>>> '{:f}'.format(float('1e20'))
'100000000000000000000.000000'

Python does this conversion automatically. Just try it.
a = +1.488763E+01
print(a)
14.88763

It’s a decimal, it already is a float. Though if you print it, python will automatically put it in the format you want.
As long as you don’t have it as a string, it’ll be in the format you want it.
a = +1.488763E+01
print(a)
14.88763

You can use float() function
float(a)

Getting error in python: Value Error: invalid literal for int() with base 10: '470.21'

i want adding and subtracting this type of data: $12,587.30.which returns answer in same format.how can do this ?
Here is my code example:
print(int(col_ammount2.lstrip('$'))-int(col_ammount.lstrip('$')))
I removed $ sign and convert it to int but it gives me base 10 error.

You mentioned you want to do arithmetic operations to the numbers (addition/subtraction) so you probably want them in float instead. The difference between an integer (int) and float is that integers do not carry decimal points.
Additionally, as #officialaimm mentioned you need to remove the commas too, for example
float('$3,333.33'.replace('$', '').replace(',', ''))
will give you
3333.33
So putting it into your code
print(float(col_ammount2.lstrip('$').replace(',', ''))
- float(col_ammount.lstrip('$').replace(',', '')))
An additional note for when you parse a floating point number (same applies to integers too), you may want to watch out for empty values, i.e.
float('')
is bad. One of the things u can do in case col_amount and col_amount2 may be empty at some point is default them to 0 if that happens
float(col_amount.lstrip(...).replace(...) or 0)
You also want to read this to know about workaround to problems you may face with floating point arithmetic https://docs.python.org/3/tutorial/floatingpoint.html

There are two things you are missing here. Firstly python int(...) cannot parse numbers with commas so you will need to remove commas as well by using .replace(',',''). Secondly int() cannot parse floating point values you will have to use float(...) first and after that maybe typecast it to int using int or math.ceil, math.floor appropriately as per your choice and needs.
Maybe something like this will solve your problem:
col_ammount2='$1,587.30'
col_ammount = '$2,567.67'
print(int(float(col_ammount2.lstrip('$').replace(',','')))-int(float(col_ammount.lstrip('$').replace(',',''))))
If you are doing these sorts of things quite often in your code, making a function as such might be handy:
integerify_currency = lambda x:int(float(x.lstrip('$').replace(',','')))

Python int too large to convert to C long in Python COM

I have a python method that calculates value and returns it.
The value is
CalcData = 3941269503L.
It is only 32 bit. Yet this is typecasted to long implicitly (suffixed by L) and when I access this method in COM in other application , I get the Python int too large to convert to C long error. I even tried typecasting it into int,but no luck

The "long" C type is signed so the largest positive value it can store is 2,147,483,647. The error is indeed correct, it doesn't fit.
Try "unsigned long" and "UL" postfix on the constant.

Python : Do not include "L" at the end of the outcome for : randint(100000000000000000000, 999999999999999999999)

so far this is what i found:
from random import randint
randint(100000000000000000000, 999999999999999999999)
the output is:
922106555361958347898L
but i do not want that L there..
i can only use this as an int if there is no "L" there at the end of it.
UPDATE
would it be a better idea to generate two small numbers and then combine them if the goal is to simply have a random number that is 30 digits long ?

The reason there's an L there is because this is too large to fit into an int,* so it's a long. See Numeric Types — int, long, float, complex in the docs for more details.
So, why do you get that L, and how do you get rid of it?
Python has two different ways to turn a value into a string representation:
repr either returns the canonical source-code representation, or something like <__main__.Eggs at 0x10fbd8908>).
str returns a human-friendly representation.
For example, for strings, str('abc') is abc, while repr('abc') is 'abc'.
And for longs, str(1L) is 1, while repr(1L) is 1L.
When you just type an expression at the interactive prompt, it uses repr. But when you use the print command, it uses str. So, if you want to see the value without the L, just print it:
print randint(100000000000000000000, 999999999999999999999)
If you want to, e.g., save the string in a variable or write it to a file, you have to call str explicitly.
But if you just want to use it as a number, you don't have to worry about this at all; it's a number, and int and long values can be intermixed freely (as of Python 2.3 or so).
And if you're trying to store it in a MySQL database, whichever MySQL interface you use won't care whether you're giving it int values or long, as long as they fit into the column type.**
Or you could upgrade to Python 3.x, where there is no separate long type anymore (all integers are int, no matter how big) and no L suffix.
* The exact cutoff isn't documented anywhere, but at least for CPython, it's whatever fits into a C long on your platform. So, on most 64-bit platforms, the max value is (1<<63)-1; on the other 64-bit platforms, and all 32-bit platforms, it's (1<<31)-1. You can see for yourself on your platform by printing sys.maxint. At any rate, your number takes 70 bits, so unless someone ports Python 2.x to a platform with 128-bit C longs, it won't fit.
** Note that your values are too big to fit into even a MySQL BIGINT, so you're going to be using either DECIMAL or NUMERIC. Depending on which interface you're using, and how you've set things up, you may have to convert to and from strings manually. But you can do that with the str and int functions, without worrying about which values fit into the int type and which don't.)

If you're on the interactive prompt, explicitly print the value. The repr of the value has an L, but the str of the value doesn't.
>>> 922106555361958347898
922106555361958347898L
>>> print 922106555361958347898
922106555361958347898

The output in the REPL has an L suffixed; if you print the value, it is not displayed.
>>> from random import randint
>>> print randint(100000000000000000000, 999999999999999999999)
106315199286113607384
>>>

How is the conversion in the python struct module done?

I need to unpack information in python from a C Structure,
doing it by the following code:
struct.unpack_from('>I', file.read(4))[0]
and afterwards, writing changed values back:
new_value = struct.pack('>I', 008200)
file.write(new_value)
a few examples:
008200 returns an syntaxerror: invalid token.
000010 is written into: 8
000017 is written into: 15
000017 returns a syntaxerror.
I have no idea what kind of conversion that is.
Any kind of help would be great.

This is invalid python code and is not related to the struct module. In python, numbers starting with a zero are octal (base 8). So, python tries to decode 008200 in octal but '8' isn't valid. Assuming you wanted decimal, use 8200. If you wanted hex, use 0x8200.